White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany.
Identifieur interne : 000033 ( Main/Exploration ); précédent : 000032; suivant : 000034White-Tailed Sea Eagle (Haliaeetus albicilla) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany.
Auteurs : Oliver Krone [Allemagne] ; Anja Globig [Allemagne] ; Reiner Ulrich [Allemagne] ; Timm Harder [Allemagne] ; Jan Schinköthe [Allemagne] ; Christof Herrmann [Allemagne] ; Sascha Gerst [Allemagne] ; Franz J. Conraths [Allemagne] ; Martin Beer [Allemagne]Source :
- Viruses [ 1999-4915 ] ; 2018.
Descripteurs français
- KwdFr :
- Aigles (virologie), Allemagne (épidémiologie), Analyse de séquence d'ADN (MeSH), Animaux (MeSH), Encéphalite (anatomopathologie), Encéphalite (étiologie), Grippe chez les oiseaux (anatomopathologie), Grippe chez les oiseaux (mortalité), Grippe chez les oiseaux (virologie), Grippe chez les oiseaux (épidémiologie), Immunohistochimie (MeSH), Réaction de polymérisation en chaine en temps réel (MeSH), Sous-type H5N8 du virus de la grippe A (isolement et purification), Sous-type H5N8 du virus de la grippe A (pathogénicité).
- MESH :
- anatomopathologie : Encéphalite, Grippe chez les oiseaux.
- isolement et purification : Sous-type H5N8 du virus de la grippe A.
- mortalité : Grippe chez les oiseaux.
- pathogénicité : Sous-type H5N8 du virus de la grippe A.
- virologie : Aigles, Grippe chez les oiseaux.
- épidémiologie : Allemagne, Grippe chez les oiseaux.
- étiologie : Encéphalite.
- Analyse de séquence d'ADN, Animaux, Immunohistochimie, Réaction de polymérisation en chaine en temps réel.
English descriptors
- KwdEn :
- Animals (MeSH), Eagles (virology), Encephalitis (etiology), Encephalitis (pathology), Germany (epidemiology), Immunohistochemistry (MeSH), Influenza A Virus, H5N8 Subtype (isolation & purification), Influenza A Virus, H5N8 Subtype (pathogenicity), Influenza in Birds (epidemiology), Influenza in Birds (mortality), Influenza in Birds (pathology), Influenza in Birds (virology), Real-Time Polymerase Chain Reaction (MeSH), Sequence Analysis, DNA (MeSH).
- MESH :
- epidemiology : Germany, Influenza in Birds.
- etiology : Encephalitis.
- isolation & purification : Influenza A Virus, H5N8 Subtype.
- mortality : Influenza in Birds.
- pathogenicity : Influenza A Virus, H5N8 Subtype.
- pathology : Encephalitis, Influenza in Birds.
- virology : Eagles, Influenza in Birds.
- Animals, Immunohistochemistry, Real-Time Polymerase Chain Reaction, Sequence Analysis, DNA.
Abstract
In contrast to previous incursions of highly pathogenic avian influenza (HPAIV) H5 viruses, H5N8 clade 2.3.4.4b viruses caused numerous cases of lethal infections in white-tailed sea eagles (Haliaeetus albicilla) affecting mainly young eagles (younger than five years of age) in Germany during winter 2016/2017. Until April 2017, 17 HPAIV H5N8-positive white-tailed sea eagles had been detected (three found alive and 14 carcasses) by real-time RT-PCR and partial nucleotide sequence analyses. Severe neurological clinical signs were noticed which were corroborated by immunohistopathology revealing mild to moderate, oligo- to multifocal necrotizing virus-induced polioencephalitis. Lethal lead (Pb) concentrations, a main factor of mortality in sea eagles in previous years, could be ruled out by atomic absorption spectrometry. HPAIV H5 clade 2.3.4.4b reportedly is the first highly pathogenic influenza virus known to induce fatal disease in European white-tailed see eagles. This virus strain may become a new health threat to a highly protected species across its distribution range in Eurasia. Positive cloacal swabs suggest that eagles can spread the virus with their faeces.
DOI: 10.3390/v10090478
PubMed: 30205456
PubMed Central: PMC6163648
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Christof.Herrmann@lung.mv-regierung.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Agency for Environment, Nature Conservation, and Geology Mecklenburg-Western Pomerania, 18273 Güstrow</wicri:regionArea><wicri:noRegion>18273 Güstrow</wicri:noRegion><wicri:noRegion>18273 Güstrow</wicri:noRegion><wicri:noRegion>18273 Güstrow</wicri:noRegion></affiliation></author><author><name sortKey="Gerst, Sascha" sort="Gerst, Sascha" uniqKey="Gerst S" first="Sascha" last="Gerst">Sascha Gerst</name><affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic Investigation of Epizootics (LALLF), State Office for Agriculture, Food Safety, and Fishery, Mecklenburg-Western Pomerania, 18059 Rostock, Germany. sascha.gerst@lallf.mvnet.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic Investigation of Epizootics (LALLF), State Office for Agriculture, Food Safety, and Fishery, Mecklenburg-Western Pomerania, 18059 Rostock</wicri:regionArea><wicri:noRegion>18059 Rostock</wicri:noRegion><wicri:noRegion>18059 Rostock</wicri:noRegion><wicri:noRegion>18059 Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Conraths, Franz J" sort="Conraths, Franz J" uniqKey="Conraths F" first="Franz J" last="Conraths">Franz J. Conraths</name><affiliation wicri:level="1"><nlm:affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Franz.Conraths@fli.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Beer, Martin" sort="Beer, Martin" uniqKey="Beer M" first="Martin" last="Beer">Martin Beer</name><affiliation wicri:level="1"><nlm:affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Martin.Beer@fli.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30205456</idno><idno type="pmid">30205456</idno><idno type="doi">10.3390/v10090478</idno><idno type="pmc">PMC6163648</idno><idno type="wicri:Area/Main/Corpus">000028</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000028</idno><idno type="wicri:Area/Main/Curation">000028</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000028</idno><idno type="wicri:Area/Main/Exploration">000028</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">White-Tailed Sea Eagle (<i>Haliaeetus albicilla</i>) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany.</title><author><name sortKey="Krone, Oliver" sort="Krone, Oliver" uniqKey="Krone O" first="Oliver" last="Krone">Oliver Krone</name><affiliation wicri:level="3"><nlm:affiliation>Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, 10315 Berlin, Germany. krone@izw-berlin.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, 10315 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Globig, Anja" sort="Globig, Anja" uniqKey="Globig A" first="Anja" last="Globig">Anja Globig</name><affiliation wicri:level="1"><nlm:affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Anja.Globig@fli.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Ulrich, Reiner" sort="Ulrich, Reiner" uniqKey="Ulrich R" first="Reiner" last="Ulrich">Reiner Ulrich</name><affiliation wicri:level="1"><nlm:affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Reiner.Ulrich@fli.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Harder, Timm" sort="Harder, Timm" uniqKey="Harder T" first="Timm" last="Harder">Timm Harder</name><affiliation wicri:level="1"><nlm:affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Timm.Harder@fli.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Schinkothe, Jan" sort="Schinkothe, Jan" uniqKey="Schinkothe J" first="Jan" last="Schinköthe">Jan Schinköthe</name><affiliation wicri:level="1"><nlm:affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. jan.schinkoethe@fli.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Herrmann, Christof" sort="Herrmann, Christof" uniqKey="Herrmann C" first="Christof" last="Herrmann">Christof Herrmann</name><affiliation wicri:level="1"><nlm:affiliation>Agency for Environment, Nature Conservation, and Geology Mecklenburg-Western Pomerania, 18273 Güstrow, Germany. Christof.Herrmann@lung.mv-regierung.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Agency for Environment, Nature Conservation, and Geology Mecklenburg-Western Pomerania, 18273 Güstrow</wicri:regionArea><wicri:noRegion>18273 Güstrow</wicri:noRegion><wicri:noRegion>18273 Güstrow</wicri:noRegion><wicri:noRegion>18273 Güstrow</wicri:noRegion></affiliation></author><author><name sortKey="Gerst, Sascha" sort="Gerst, Sascha" uniqKey="Gerst S" first="Sascha" last="Gerst">Sascha Gerst</name><affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic Investigation of Epizootics (LALLF), State Office for Agriculture, Food Safety, and Fishery, Mecklenburg-Western Pomerania, 18059 Rostock, Germany. sascha.gerst@lallf.mvnet.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic Investigation of Epizootics (LALLF), State Office for Agriculture, Food Safety, and Fishery, Mecklenburg-Western Pomerania, 18059 Rostock</wicri:regionArea><wicri:noRegion>18059 Rostock</wicri:noRegion><wicri:noRegion>18059 Rostock</wicri:noRegion><wicri:noRegion>18059 Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Conraths, Franz J" sort="Conraths, Franz J" uniqKey="Conraths F" first="Franz J" last="Conraths">Franz J. Conraths</name><affiliation wicri:level="1"><nlm:affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Franz.Conraths@fli.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Beer, Martin" sort="Beer, Martin" uniqKey="Beer M" first="Martin" last="Beer">Martin Beer</name><affiliation wicri:level="1"><nlm:affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Martin.Beer@fli.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Eagles (virology)</term><term>Encephalitis (etiology)</term><term>Encephalitis (pathology)</term><term>Germany (epidemiology)</term><term>Immunohistochemistry (MeSH)</term><term>Influenza A Virus, H5N8 Subtype (isolation & purification)</term><term>Influenza A Virus, H5N8 Subtype (pathogenicity)</term><term>Influenza in Birds (epidemiology)</term><term>Influenza in Birds (mortality)</term><term>Influenza in Birds (pathology)</term><term>Influenza in Birds (virology)</term><term>Real-Time Polymerase Chain Reaction (MeSH)</term><term>Sequence Analysis, DNA (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aigles (virologie)</term><term>Allemagne (épidémiologie)</term><term>Analyse de séquence d'ADN (MeSH)</term><term>Animaux (MeSH)</term><term>Encéphalite (anatomopathologie)</term><term>Encéphalite (étiologie)</term><term>Grippe chez les oiseaux (anatomopathologie)</term><term>Grippe chez les oiseaux (mortalité)</term><term>Grippe chez les oiseaux (virologie)</term><term>Grippe chez les oiseaux (épidémiologie)</term><term>Immunohistochimie (MeSH)</term><term>Réaction de polymérisation en chaine en temps réel (MeSH)</term><term>Sous-type H5N8 du virus de la grippe A (isolement et purification)</term><term>Sous-type H5N8 du virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphalite</term><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Germany</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Encephalitis</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H5N8 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H5N8 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N8 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H5N8 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Encephalitis</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Aigles</term><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Eagles</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Encéphalite</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Immunohistochemistry</term><term>Real-Time Polymerase Chain Reaction</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Immunohistochimie</term><term>Réaction de polymérisation en chaine en temps réel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In contrast to previous incursions of highly pathogenic avian influenza (HPAIV) H5 viruses, H5N8 clade 2.3.4.4b viruses caused numerous cases of lethal infections in white-tailed sea eagles (<i>Haliaeetus albicilla</i>) affecting mainly young eagles (younger than five years of age) in Germany during winter 2016/2017. Until April 2017, 17 HPAIV H5N8-positive white-tailed sea eagles had been detected (three found alive and 14 carcasses) by real-time RT-PCR and partial nucleotide sequence analyses. Severe neurological clinical signs were noticed which were corroborated by immunohistopathology revealing mild to moderate, oligo- to multifocal necrotizing virus-induced polioencephalitis. Lethal lead (Pb) concentrations, a main factor of mortality in sea eagles in previous years, could be ruled out by atomic absorption spectrometry. HPAIV H5 clade 2.3.4.4b reportedly is the first highly pathogenic influenza virus known to induce fatal disease in European white-tailed see eagles. This virus strain may become a new health threat to a highly protected species across its distribution range in Eurasia. Positive cloacal swabs suggest that eagles can spread the virus with their faeces.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30205456</PMID><DateCompleted><Year>2018</Year><Month>11</Month><Day>12</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1999-4915</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>9</Issue><PubDate><Year>2018</Year><Month>09</Month><Day>07</Day></PubDate></JournalIssue><Title>Viruses</Title><ISOAbbreviation>Viruses</ISOAbbreviation></Journal><ArticleTitle>White-Tailed Sea Eagle (<i>Haliaeetus albicilla</i>) Die-Off Due to Infection with Highly Pathogenic Avian Influenza Virus, Subtype H5N8, in Germany.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E478</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/v10090478</ELocationID><Abstract><AbstractText>In contrast to previous incursions of highly pathogenic avian influenza (HPAIV) H5 viruses, H5N8 clade 2.3.4.4b viruses caused numerous cases of lethal infections in white-tailed sea eagles (<i>Haliaeetus albicilla</i>) affecting mainly young eagles (younger than five years of age) in Germany during winter 2016/2017. Until April 2017, 17 HPAIV H5N8-positive white-tailed sea eagles had been detected (three found alive and 14 carcasses) by real-time RT-PCR and partial nucleotide sequence analyses. Severe neurological clinical signs were noticed which were corroborated by immunohistopathology revealing mild to moderate, oligo- to multifocal necrotizing virus-induced polioencephalitis. Lethal lead (Pb) concentrations, a main factor of mortality in sea eagles in previous years, could be ruled out by atomic absorption spectrometry. HPAIV H5 clade 2.3.4.4b reportedly is the first highly pathogenic influenza virus known to induce fatal disease in European white-tailed see eagles. This virus strain may become a new health threat to a highly protected species across its distribution range in Eurasia. Positive cloacal swabs suggest that eagles can spread the virus with their faeces.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krone</LastName><ForeName>Oliver</ForeName><Initials>O</Initials><Identifier Source="ORCID">0000-0002-4507-5124</Identifier><AffiliationInfo><Affiliation>Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, 10315 Berlin, Germany. krone@izw-berlin.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Globig</LastName><ForeName>Anja</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Anja.Globig@fli.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ulrich</LastName><ForeName>Reiner</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Reiner.Ulrich@fli.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harder</LastName><ForeName>Timm</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Timm.Harder@fli.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schinköthe</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. jan.schinkoethe@fli.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herrmann</LastName><ForeName>Christof</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Agency for Environment, Nature Conservation, and Geology Mecklenburg-Western Pomerania, 18273 Güstrow, Germany. Christof.Herrmann@lung.mv-regierung.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gerst</LastName><ForeName>Sascha</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Diagnostic Investigation of Epizootics (LALLF), State Office for Agriculture, Food Safety, and Fishery, Mecklenburg-Western Pomerania, 18059 Rostock, Germany. sascha.gerst@lallf.mvnet.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conraths</LastName><ForeName>Franz J</ForeName><Initials>FJ</Initials><Identifier Source="ORCID">0000-0002-7400-9409</Identifier><AffiliationInfo><Affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Franz.Conraths@fli.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beer</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany. Martin.Beer@fli.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>09</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Viruses</MedlineTA><NlmUniqueID>101509722</NlmUniqueID><ISSNLinking>1999-4915</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020307" MajorTopicYN="N">Eagles</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004660" MajorTopicYN="N">Encephalitis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000071225" MajorTopicYN="N">Influenza A Virus, H5N8 Subtype</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">HPAIV H5N8 clade 2.3.4.4b</Keyword><Keyword MajorTopicYN="Y">fatal infection</Keyword><Keyword MajorTopicYN="Y">neurological symptoms</Keyword><Keyword MajorTopicYN="Y">white-tailed sea eagle</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>08</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>09</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30205456</ArticleId><ArticleId IdType="pii">v10090478</ArticleId><ArticleId IdType="doi">10.3390/v10090478</ArticleId><ArticleId IdType="pmc">PMC6163648</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Vet Res. 2015 Mar 05;46:24</Citation><ArticleIdList><ArticleId IdType="pubmed">25879698</ArticleId></ArticleIdList></Reference><Reference><Citation>Transbound Emerg Dis. 2016 Feb;63(1):10-3</Citation><ArticleIdList><ArticleId 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Conraths</name><name sortKey="Gerst, Sascha" sort="Gerst, Sascha" uniqKey="Gerst S" first="Sascha" last="Gerst">Sascha Gerst</name><name sortKey="Globig, Anja" sort="Globig, Anja" uniqKey="Globig A" first="Anja" last="Globig">Anja Globig</name><name sortKey="Harder, Timm" sort="Harder, Timm" uniqKey="Harder T" first="Timm" last="Harder">Timm Harder</name><name sortKey="Herrmann, Christof" sort="Herrmann, Christof" uniqKey="Herrmann C" first="Christof" last="Herrmann">Christof Herrmann</name><name sortKey="Schinkothe, Jan" sort="Schinkothe, Jan" uniqKey="Schinkothe J" first="Jan" last="Schinköthe">Jan Schinköthe</name><name sortKey="Ulrich, Reiner" sort="Ulrich, Reiner" uniqKey="Ulrich R" first="Reiner" last="Ulrich">Reiner Ulrich</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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